Studies in Carcinogenesis with Azo Compounds II. The Action of Azo Compounds in Mice, and the Bearing Thereof on Theories of Azo Dye Carcinogenesis*

The results of earlier investigations of the carcinogenic action of azo dyes in rats were summarized by Kinosita in 1937 and 1940 (22, 23), and by Hartwell in 1941 (17). Since then much work has been done involving various types of controlled, restricted diets and a theory has been evolved (19) to account for the activity of certain dyes and the inactivity of others. A short review of this work appeared in a recent paper by Miller and Baumann (29), who criticized the theory on the basis of their own experimental findings. A considerable amount of work on mice has been carried out with azo compounds since the earlier reviews appeared, but no attempt has been made to examine it critically and to determine its bearing on the "split product" theory of carcinogenesis. In this paper, in a series of tables, there has been